Selective serotonin reuptake inhibitors (SSRIs) generally don't cause weight gain because the antidepressants boost serotonin, which helps you feel full. it's unusual to gain weight on wellbutrin. it actually is a med that is weight-neutral, so many drugs say they are weight-neutral but really are not. some people will only take wellbutrin because they don't gain weight on it. Although weight gain is a potential side effect of Wellbutrin, the medicine is more likely to cause weight loss. If you are taking Wellbutrin and weight gain does become a problem, be sure to talk with your healthcare provider. Six medications you never knew could cause weight gain, and what to do if you currently take one of them. Although Prozac can cause some initial weight loss, it may cause weight gain in the long run. What can you do to lose weight when using Prozac? Wellbutrin has been scientifically proven to help people lose weight (up to 10% of their body weight). Learn who should use it and how to use it safely. A: Changes in weight and appetite are common side effects of Wellbutrin (bupropion). Some patients find that switching to another antidepressant can help with weight gain. Drugs.com information on Ativan lists weight gain as a possible side effect, but lists weight loss under side effects whose incidence is unknown. Whether you are seeking treatment for depression and don't want to gain weight, or you want to consider using an antidepressant to help with weight loss, knowing how these medications affect metabolism and appetite can help guide your decision making process. Medications do not replace the need to My experience is very similar. I was 125 lbs when I started taking Paxil for anxiety and gained about 40lbs over the course of 2 years. I started on Wellbutrin at the suggestion of my Dr. when I advised that I no longer wanted to take it due to the horrible weight gain.